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Volume 156, Issue 1, Pages e5 (January 2019)

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1 Volume 156, Issue 1, Pages 88-95.e5 (January 2019)
Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis  Rohit Loomba, Arun J. Sanyal, Kris V. Kowdley, Norah Terrault, Naga P. Chalasani, Manal F. Abdelmalek, Arthur J. McCullough, Reshma Shringarpure, Beatrice Ferguson, Lois Lee, Jianfen Chen, Alexander Liberman, David Shapiro, Brent A. Neuschwander-Tetri  Gastroenterology  Volume 156, Issue 1, Pages e5 (January 2019) DOI: /j.gastro Copyright © 2019 AGA Institute Terms and Conditions

2 Figure 1 Forest plot of predictors of histologic response. Plot shows the odds ratio and 95% CIs for each of the selected predictors of responses. If the odds ratio is >1, the predictor is associated with higher odds of histologic response. Significance of each of the selected predictors was assessed using a Wald chi-squared test. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2019 AGA Institute Terms and Conditions

3 Figure 2 ROC curves. The ROC curve for the overall population (N = 200) is shown in red, the ROC curve for patients receiving OCA (n = 102) is shown in purple, and the ROC curve for patients receiving placebo (n = 98) is shown in black. The model was significant when applied to the overall population, as well as to each of the treatment groups (P < for all). Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2019 AGA Institute Terms and Conditions

4 Figure 3 Scatterplot of model predictions. Scatterplot shows the probability of histologic response and accuracy of each prediction for all patients assessed in this analysis. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2019 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Model development. The jackknife method systematically removes 1 observation (patient) at a time and reassesses the entire model. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2019 AGA Institute Terms and Conditions


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