1. Spectrum of cellular processes regulated by AXL activity
Figure 1 from Gay et al.
British Journal of Cancer Advance Online Publication
10 January 2017 doi: /bjc
Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies.
© 2017 The Author(s).