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Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice  Fu-Gang Zhu, PhD, Ekambar R. Kandimalla,

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Presentation on theme: "Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice  Fu-Gang Zhu, PhD, Ekambar R. Kandimalla,"— Presentation transcript:

1 Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice  Fu-Gang Zhu, PhD, Ekambar R. Kandimalla, PhD, Dong Yu, PhD, Sudhir Agrawal, DPhil  Journal of Allergy and Clinical Immunology  Volume 120, Issue 3, Pages (September 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 PN-specific antibody responses in the intestine (mucosal, open bars) and serum (systemic, solid bars) after oral coadministration of IMO with PN in the prevention model. Serum and intestinal samples were collected after the final PN challenge on day 28 and assayed for PN-specific immunoglobulin levels by using ELISA. The results represent the mean of 5 mice in each group (± SD). ∗P < .05 compared with the PN-sensitized and PN-challenged group. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Histology of small (A) and large (B) intestinal sections of the mice in the prevention study. Intestinal samples were collected after the final PN challenge on day 28 and stained with hematoxylin and eosin. The microphotographs were taken at 200× magnification. Severe infiltration of inflammatory cells with prominent presence of eosinophils and loss of normal mucosal structure is indicated with arrows. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 The PN-specific antibody responses in the intestine (mucosal, open bars) and serum (systemic, solid bars) on day 34 in the treatment study. The results represent the mean of 5 mice in each group (± SD). IgE levels were significantly decreased and IgG2a and IgA levels were increased in the IMO-treated group compared with those in the PN-sensitized and PN-challenged group (∗P < .05). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Histology of small intestinal sections of the mice in the treatment study. Intestinal samples were collected after final PN challenge and stained with naphtol AS-D chloroacetate and counterstained with hematoxylin. The microphotographs were taken at ×400 magnification. Mast cell aggregates (red-stained) are present in the small intestines of PN-sensitized mice. The mast cell infiltration in the intestine of IMO-treated mice was reduced. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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