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Figure 2 Phenotypes of osteoarthritis

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Presentation on theme: "Figure 2 Phenotypes of osteoarthritis"— Presentation transcript:

1 Figure 2 Phenotypes of osteoarthritis
Figure 2 | Phenotypes of osteoarthritis. Evidence suggests that patients with osteoarthritis (OA) fall into multiple phenotypic subgroups defined on the basis of the main driver of disease, one of which is a distinct metabolic phenotype, although all OA phenotypes probably involve metabolic alterations. Cartilage, bone and synovium are all affected by external and internal drivers of disease such as inflammation, injury or biomechanical alterations, metabolic reprogramming and immunomodulation, but different synovial joint tissues dominate the disease in different patients with OA. Mobasheri, A. et al. (2017) The role of metabolism in the pathogenesis of osteoarthritis Nat. Rev. Rheumatol. doi: /nrrheum

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Figure 1 Lymphocytes during the disease

Figure 1 Lymphocytes during the disease
Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,
Figure 4 Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations Figure 4 | Tissue infiltration and lymphadenopathy in patients with CTLA4.

Figure 4 Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations Figure 4 | Tissue infiltration and lymphadenopathy in patients with CTLA4.
Figure 3 The adaptive and maladaptive energy matrices

Figure 3 The adaptive and maladaptive energy matrices
Figure 3 Connexins in cartilage

Figure 3 Connexins in cartilage
Figure 3 Metabolism in homeostatic chondrocytes

Figure 3 Metabolism in homeostatic chondrocytes
Figure 2 Representative MSI data obtained from human joints

Figure 2 Representative MSI data obtained from human joints
Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 3 Neuromuscular exercise

Figure 3 Neuromuscular exercise
Figure 1 Enthesitis versus synovitis

Figure 1 Enthesitis versus synovitis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Factors underlying metabolic alterations in osteoarthritis
Figure 2 Risk factors for sarcopenia

Figure 2 Risk factors for sarcopenia
Figure 7 The efficacy of phosphate-binder therapy

Figure 7 The efficacy of phosphate-binder therapy
Figure 2 Main functions of IL-1

Figure 2 Main functions of IL-1
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 2 Targeted versus untargeted metabolomics approaches

Figure 2 Targeted versus untargeted metabolomics approaches
Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

Figure 1 Metabolic profiling as a tool for studying rheumatic diseases
Figure 1 Schematic comparison of expected

Figure 1 Schematic comparison of expected

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