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The Relationship between the Sibling Recurrence-Risk Ratio and Genotype Relative Risk
Benjamin A. Rybicki, Robert C. Elston The American Journal of Human Genetics Volume 66, Issue 2, Pages (February 2000) DOI: /302778 Copyright © 2000 The American Society of Human Genetics Terms and Conditions
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Figure 1 A, Relationship between λS and γ for disease-susceptibility allele frequencies of .01–.5 under a single-locus dominant-inheritance model. B, Relationship between λS and γ for disease-susceptibility-allele frequencies of .01–.5 under a single-locus recessive-inheritance model. The American Journal of Human Genetics , DOI: ( /302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions
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Figure 2 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 1), in which at least one disease-susceptibility allele from each locus must be present for increased disease risk. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 2), in which two copies of a disease-susceptibility allele from each locus must be present for increased disease risk. C, Relationship between λS and γ, for disease-susceptibility allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 3), in which a total of three or more copies of a disease-susceptibility allele from both loci must be present for increased disease risk. The American Journal of Human Genetics , DOI: ( /302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions
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Figure 3 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus dominant-additive-inheritance model. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus recessive-additive-inheritance model. The American Journal of Human Genetics , DOI: ( /302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions
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Figure 4 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus dominant-multiplicative -inheritance model. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus recessive-multiplicative-inheritance model. The American Journal of Human Genetics , DOI: ( /302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions
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