Presentation is loading. Please wait.

Presentation is loading. Please wait.

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment  Juan A. Crestanello, MD.

Published byRudolf Veres Modified over 5 years ago

Similar presentations

Presentation on theme: "Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment  Juan A. Crestanello, MD."— Presentation transcript:

1 Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment  Juan A. Crestanello, MD (by invitation), Joseph Kamelgard, MD (by invitation), David M. Lingle, MD (by invitation), Svend A. Mortensen, MD (by invitation), Morten Rhode, (by invitation), Glenn J.R. Whitman, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 111, Issue 2, Pages (February 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 Fig. 1 Recovery of mechanical function during reperfusion expressed as a percentage of end-equilibration left ventricular DP. Asterisk indicates p < versus control. Note improvement afforded by CoQ10 pretreatment. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 Fig. 2 DP/MVo2 during equilibration and at end-reperfusion. During reperfusion CoQ10 hearts maintained their preischemic efficiency, in contrast to control hearts. Asterisk indicates p < 0.05 versus CoQ10 group at reperfusion and vs both groups at equilibration. V, Ventricle. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 Fig. 3 Myocardial CK activity at end-equilibration and at end-reperfusion. Hearts pretreated with CoQ10 maintained greater CK activity than did control hearts. Asterisk indicates p < 0.05 versus control at reperfusion. V, Ventricle. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 Fig. 4 Phosphocreatine (PCr) levels during equilibration (EQ) and during reperfusion (RP). CoQ10 hearts showed higher levels during both equilibration and reperfusion. Asterisk indicates p < versus control. Horizontal axis indicates time in minutes. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 Fig. 5 ATP levels during equilibration (EQ) and during reperfusion (RP). CoQ10 hearts showed higher levels during both equilibration and reperfusion. Asterisk indicates p < 0.05 versus control. Horizontal axis indicates time in minutes. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

Download ppt "Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment  Juan A. Crestanello, MD."

Similar presentations

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.
Manuel J. Antunes, MD, PhD, DSc 

Manuel J. Antunes, MD, PhD, DSc 
Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts  Sidney Chocron, MDa, Kifah Alwan, MDa, Gerard Toubin, MDb,

Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts  Sidney Chocron, MDa, Kifah Alwan, MDa, Gerard Toubin, MDb,
Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat  Ryuzo Bessho, MD, PhD, David J. Chambers,

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat  Ryuzo Bessho, MD, PhD, David J. Chambers,
Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery  Manuel Castellá, MD, Gerald D.

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery  Manuel Castellá, MD, Gerald D.
Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel 

Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel 
Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model  Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.

Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model  Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.
Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size  Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,

Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size  Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,
Thrombosis of the pulmonary artery stump after distal ligation

Thrombosis of the pulmonary artery stump after distal ligation
B. Albat, MD, P. Messner-Pellenc, MD, A. Thévenet, MD 

B. Albat, MD, P. Messner-Pellenc, MD, A. Thévenet, MD 
Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury  Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,

Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury  Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,
Klaus Langes, MD, Dietmar Koschyk, MD, Detlef G. Mathey, MD 

Klaus Langes, MD, Dietmar Koschyk, MD, Detlef G. Mathey, MD 
Amine Mazine, MD, MSc, Subodh Verma, MD, PhD, Bobby Yanagawa, MD, PhD 

Amine Mazine, MD, MSc, Subodh Verma, MD, PhD, Bobby Yanagawa, MD, PhD 
Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J
Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.
Juan A. Crestanello, MD, Richard C. Daly, MD 

Juan A. Crestanello, MD, Richard C. Daly, MD 
Centers for Disease Control “increased-risk” organ donor: Not so risky?  Francis D. Pagani, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery 

Centers for Disease Control “increased-risk” organ donor: Not so risky?  Francis D. Pagani, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery 
Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD,

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD,
Daniel R. Meldrum, MD, Joseph C. Cleveland, MD, Brett C

Daniel R. Meldrum, MD, Joseph C. Cleveland, MD, Brett C
Implantation of a left ventricular assist device, back-to-front, in an adolescent with a failing mustard procedure  Lars Wiklund, MD, PhD, Sveneric Svensson,

Implantation of a left ventricular assist device, back-to-front, in an adolescent with a failing mustard procedure  Lars Wiklund, MD, PhD, Sveneric Svensson,

Similar presentations

Ads by Google