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Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease  Michael S. Levine, Carlos Cepeda,

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Presentation on theme: "Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease  Michael S. Levine, Carlos Cepeda,"— Presentation transcript:

1 Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease  Michael S. Levine, Carlos Cepeda, Véronique M. André  Neuron  Volume 65, Issue 2, Pages (January 2010) DOI: /j.neuron Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Synaptic and Extrasynaptic Receptors in HD
The left side shows synaptic and extrasynaptic NMDA receptors functioning in a balanced manner in the normal condition. On the right in HD there is an increase in extrasynaptic NMDA receptor function due to increase in either the number of receptors and/or an increase in extracellular glutamate that shifts the functional balance toward the extrasynaptic receptors enhancing the proapoptotic pathway. Neuron  , DOI: ( /j.neuron ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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