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Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse  Saad S. Kenderian, David L. Porter,

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Presentation on theme: "Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse  Saad S. Kenderian, David L. Porter,"— Presentation transcript:

1 Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse  Saad S. Kenderian, David L. Porter, Saar Gill  Biology of Blood and Marrow Transplantation  Volume 23, Issue 2, Pages (February 2017) DOI: /j.bbmt Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Composition of a CAR. A CAR is composed of an extracellular single-chain variable fragment, linked to a transmembrane domain (CD8 or CD28) through a hinge (CD8 or IgG4), 1 or more intracellular costimulatory molecules (41BB, CD28, CD27, ICOS, and/or OX40), and a CD3z signaling molecule. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Schematic showing how CART cell therapy can be incorporated in hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Schematic showing how myeloid CART cell therapy can be used in a novel conditioning regimen as a way to induce antileukemic activity and myeloablation. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions


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