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Effect of Gender After Transcatheter Aortic Valve Implantation: A Meta-Analysis  Federico Conrotto, MD, Fabrizio D’Ascenzo, MD, Patrizia Presbitero, MD,

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Presentation on theme: "Effect of Gender After Transcatheter Aortic Valve Implantation: A Meta-Analysis  Federico Conrotto, MD, Fabrizio D’Ascenzo, MD, Patrizia Presbitero, MD,"— Presentation transcript:

1 Effect of Gender After Transcatheter Aortic Valve Implantation: A Meta-Analysis 
Federico Conrotto, MD, Fabrizio D’Ascenzo, MD, Patrizia Presbitero, MD, Karin H. Humphries, DS, John G. Webb, MD, Stephen A. O’Connor, MD, Marie-Claude Morice, MD, Thierry Lefèvre, MD, Costanza Grasso, MD, Pierluigi Sbarra, MD, Salma Taha, MD, Pierluigi Omedè, MD, Walter Grosso Marra, MD, Stefano Salizzoni, MD, Claudio Moretti, MD, Maurizio D’Amico, MD, Giuseppe Biondi-Zoccai, MD, Fiorenzo Gaita, MD, Sebastiano Marra, MD  The Annals of Thoracic Surgery  Volume 99, Issue 3, Pages (March 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Rates of primary and secondary end points for men (red) and women (blue). Variables are reported as percentages. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Random-effects meta-analysis for 30-day mortality. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Random-effects meta-analysis for in-hospital cerebrovascular accidents. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Random-effects meta-analysis for major bleedings. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Random-effects meta-analysis for major vascular complications. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Random-effects meta-analysis for moderate to severe aortic regurgitation. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

8 Fig 7 Random-effects meta-analysis for adjusted midterm mortality. The squares indicate the mean difference and are proportional to weights used in the meta-analysis. The vertical line indicates no effect. The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. (IV = inverse variance.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

9 Fig 8 Meta-regression for (A) regression of age on point (log); (B) regression of previous cardiovascular accident (CVA) on point (log); (C) regression of transfemoral approach on point (log); (D) regression of ejection fraction (EF) on point (log); and (E) regression of renal insufficiency on point (log). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

10 Fig 9 Funnel plot of included studies. (OR = odds ratio; SE = standard error.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions


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