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Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration  Kana Matsumoto, Naoyuki Uchida, Amane Sakurai,

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Presentation on theme: "Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration  Kana Matsumoto, Naoyuki Uchida, Amane Sakurai,"— Presentation transcript:

1 Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration  Kana Matsumoto, Naoyuki Uchida, Amane Sakurai, Shuichi Taniguchi, Kunihiko Morita  Biology of Blood and Marrow Transplantation  Volume 22, Issue 11, Pages (November 2016) DOI: /j.bbmt Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Correlation between the DBS method and conventional method for busulfan (A) concentration and (B) AUC0–∞. Blood samples for analysis were collected at 2, 4, and 6 hours after the start of infusion. Correlation coefficients for A and B were R2 = .9837 (y = .9903x, P < .01) and R2 = .8725 (y = 0.9986x, P < .01), respectively. Sampling was from 10 patients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Effects of hematocrit value on the divergence between blood busulfan concentrations obtained with the DBS method and conventional method (y = .2847x − , R2 = .0539, P = .52). The hematocrit range was 18.2% to 34.1%. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions


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