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RNA Quality Control in Eukaryotes

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Presentation on theme: "RNA Quality Control in Eukaryotes"— Presentation transcript:

1 RNA Quality Control in Eukaryotes
Meenakshi K. Doma, Roy Parker  Cell  Volume 131, Issue 4, Pages (November 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Diversity of RNA Quality-Control Systems in Eukaryotes
The figure depicts some of the known RNA quality-control systems for aberrant rRNA, mRNA, and tRNA in eukaryotic cells. These and additional quality-control mechanisms are summarized in Tables 1 and 2. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

3 Figure 2 Kinetic Competition and RNA Quality Control
(A) A general model for quality-control circuits as a kinetic competition between the rate of normal function in the life of an RNA and a quality-control event that targets the RNA for degradation. (B) Three ways in which aberrant RNAs can be preferentially channeled into different quality-control fates. (i) Aberrant RNAs are defective in normal function. (ii) Normal mRNAs promote normal function and thereby reduce quality control. (iii) Aberrant ribonucleoproteins (RNPs) recruit quality-control machinery. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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