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Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection  Ata S. Moshiri,

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Presentation on theme: "Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection  Ata S. Moshiri,"— Presentation transcript:

1 Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection  Ata S. Moshiri, Ryan Doumani, Lola Yelistratova, Astrid Blom, Kristina Lachance, Michi M. Shinohara, Martha Delaney, Oliver Chang, Susan McArdle, Hannah Thomas, Maryam M. Asgari, Meei-Li Huang, Stephen M. Schwartz, Paul Nghiem  Journal of Investigative Dermatology  Volume 137, Issue 4, Pages (April 2017) DOI: /j.jid Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Detection of MCPyV DNA and oncoprotein in MCC tumors. Schematic diagram of the MCPyV small and large T antigens. Numbers correspond to the nucleotide position in the MCPyV genome. The LT4 primer set targets a 60-base pair segment of the persistently expressed portion of the truncated large T antigen. The asterisk indicates the TaqMan probe location (see Materials and Methods for details). The colored brackets in the lower portion of the figure show amino acid positions of antigens used to generate the large T antibodies: CM2B4 (blue) and Ab3 (red). a. a., amino acid; MCC, Merkel cell carcinoma; MCPyV, Merkel cell polyomavirus. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Flowchart of survival analysis inclusion criteria. All patients with clinical follow-up data were included in survival analysis. For progression-free survival, patients who presented with metastatic disease were excluded from analysis. IHC, immunohistochemistry; MCC, Merkel cell carcinoma; qPCR, quantitative PCR. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 Kaplan-Meier curves of survival among MCC patients whose tumors were MCPyV-positive or -negative. (a) Patients with virus-negative tumors had significantly decreased progression-free survival (P = ). (b) Patients with virus-negative tumors had significantly decreased MCC-specific survival (P = 0.015). (c) Patients with virus-negative tumors had a nonsignificant trend for poorer overall survival (P = 0.14). MCC, Merkel cell carcinoma. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

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