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Transforming Lipoxygenases: PE-Specific Enzymes in Disguise

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Presentation on theme: "Transforming Lipoxygenases: PE-Specific Enzymes in Disguise"— Presentation transcript:

1 Transforming Lipoxygenases: PE-Specific Enzymes in Disguise
Ling F. Ye, Brent R. Stockwell  Cell  Volume 171, Issue 3, Pages (October 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 PEBP1 Associates with Lipoxygenases and Allows Them to Generate a Specific Lipid Peroxide that Promotes Ferroptosis (A) The unbound enzyme acts on free fatty acids. (B) Bound to PEBP1, lipoxygenases acquire the ability to convert membrane phosphatidylethanolamine (PE) to its oxidized form, leading to ferroptotic cell death. Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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