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The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs  Patrick Micke,

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Presentation on theme: "The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs  Patrick Micke,"— Presentation transcript:

1 The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs  Patrick Micke, MD, PhD, Johanna Sofia Margareta Mattsson, MSc, Dijana Djureinovic, MSc, Björn Nodin, PhD, Karin Jirström, MD, PhD, Lena Tran, BSc, Per Jönsson, MD, PhD, Maria Planck, MD, PhD, Johan Botling, MD, PhD, Hans Brunnström, MD, PhD  Journal of Thoracic Oncology  Volume 11, Issue 6, Pages (June 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Two cases of squamous cell carcinomas with a partly pseudoadenocarcinomatous appearance, originally suggested to be adenosquamous carcinomas on the basis of morphology alone. (A–C) Case 1 and (D–F) case 2. (A and D) Hematoxylin and eosin (B and E), CK5, and (C and F) TTF-1 staining. In both cases, the results of p40 and p63 staining were also positive, whereas that of napsin A staining was negative. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 A case of solid adenocarcinoma with mucin production in which the results of staining were positive for p63 and negative for all other markers (see the text for details). (A) Hematoxylin and eosin, (B) periodic acid-Schiff with diastase, (C) p63, and (D) TTF-1 staining. The results of staining with CK5, p40, and napsin A were also negative. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Two cases of so-called pseudosquamous adenocarcinoma originally diagnosed as poorly differentiated squamous cell carcinoma on the basis of morphology alone. (A–C) Case 1 and (D–F) case 2. (A and D) Hematoxylin and eosin, (B and E) CK5, and (C and F) TTF-1 staining. In both cases, the result of staining with napsin A was also positive, whereas that of staining with p40 was negative. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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