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Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients  Thomas D. Dayspring, MD, FACP, FNLA, Stephen.

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Presentation on theme: "Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients  Thomas D. Dayspring, MD, FACP, FNLA, Stephen."— Presentation transcript:

1 Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients  Thomas D. Dayspring, MD, FACP, FNLA, Stephen A. Varvel, PhD, Leila Ghaedi, PhD, Dawn L. Thiselton, PhD, James Bruton, MS, Joseph P. McConnell, PhD, DABCC  Journal of Clinical Lipidology  Volume 9, Issue 6, Pages (November 2015) DOI: /j.jacl Copyright © 2015 National Lipid Association Terms and Conditions

2 Figure 1 Chemical structures and formulae of the major cholesterol homeostasis biomarkers. With respect to cholesterol, sitosterol and campesterol differ by having ethyl or methyl groups, respectively, at carbon 24; cholestanol has no double bond at Δ5, lathosterol has no double bond at Δ5 but one at Δ7, and desmosterol has a diene at Δ5 and Δ24. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

3 Figure 2 Distributions of assessed noncholesterol sterols/stanols through the 99th percentile. (A) Sitosterol, (B) campesterol, (C) cholestanol, (D) desmosterol. Vertical dotted lines indicate the 25th, 50th, and 75th percentile cutpoints (N = 667,718). Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

4 Figure 3 Effect of age and sex (in 10-year increments from age 30 to 80 years) on noncholesterol sterol/stanol concentrations, N = 667,718. (A) Sitosterol, (B) campesterol, (C) cholestanol, (D) desmosterol. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

5 Figure 4 Prevalence of hypoabsorption (below 25th percentile) or hyperabsorption (above 75th percentile) or synthesis according to APOE genotype, as indicated by noncholesterol sterol/stanol levels (A) sitosterol, (B) campesterol, (C) cholestanol, (D) desmosterol. Asterisks and daggers indicate significant differences compared to APOE 3/3 genotype, P < .001. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

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