1. Model depicting the sorting of endolysosomal proteins in the Golgi complex.
Model depicting the sorting of endolysosomal proteins in the Golgi complex. Endolysosomal proteins are delivered from the ER to the Golgi complex in the same transport carriers. Once in the Golgi complex, sets of endolysosomal proteins segregate to distinct domains. One domain gives rise to tubular carriers in which endolysosomal and plasma membrane proteins leave the Golgi independently of cytosolic sorting signals and AP complexes. The other domain is the source of vesicular carriers into which endolysosomal proteins are sorted through interaction of cytosolic sorting signals with GGA proteins.
Yu Chen et al. J Cell Biol 2017;216:
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