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DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey

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Presentation on theme: "DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey"— Presentation transcript:

1 DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey
JoAnn M. Sekiguchi, David O. Ferguson  Cell  Volume 124, Issue 2, Pages (January 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Nonhomologous End-Joining in Mammalian Cells
The Ku70/Ku80 heterodimer forms a hollow ring that preferentially binds to DNA ends. Ku70/Ku80 bound to DNA ends recruits DNA-PKcs, which forms a complex with the Artemis nuclease. DNA-PKcs may tether the ends, while Artemis nucleolytically processes DNA ends prior to joining. The Cernunnos-XLF protein forms complexes with XRCC4, Ligase IV, or XRCC4 and Ligase IV simultaneously. The exact nature of the active complex is currently undefined, but could involve the formation of heteromultimers with XRCC4 or the XRCC4-Ligase IV complex. The final stage of NHEJ is the ligation of DNA ends catalyzed by XRCC4-Ligase IV. Cernunnos-XLF promotes this process in an unknown way. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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