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Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged.

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Presentation on theme: "Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged."— Presentation transcript:

1 Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged female subjects  Emily J. Blake, M.D., Paul M. Norris, M.D., Sally Faith Dorfman, M.D., MSHSA., James Longstreth, Ph.D., Vladimir I. Yankov, M.D.  Fertility and Sterility  Volume 94, Issue 4, Pages (September 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Single-day treatment phase: mean (±SEM) serum progesterone concentrations (ng/mL). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Days 1–5 of the multiple-day treatment phase: mean (±SEM) serum progesterone trough concentrations (ng/mL). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Day 5 of the multiple-day treatment phase: mean (±SEM) serum progesterone concentrations (ng/mL). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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