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Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome  Shaobo Shi, MD, PhD, Tao Liu, MD, PhD,

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Presentation on theme: "Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome  Shaobo Shi, MD, PhD, Tao Liu, MD, PhD,"— Presentation transcript:

1 Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome  Shaobo Shi, MD, PhD, Tao Liu, MD, PhD, Hector Barajas-Martinez, PhD, FHRS, Ryan Pfeiffer, BS, Hong Jiang, MD, PhD, Congxin Huang, MD, PhD, FHRS, FACC, FESC, Dan Hu, MD, PhD, FHRS, FAHA, FACC  HeartRhythm Case Reports  Volume 3, Issue 1, Pages (January 2017) DOI: /j.hrcr Copyright © 2016 Heart Rhythm Society Terms and Conditions

2 Figure 1 Proband’s ECGs before ablation. A: Baseline ECG shows positive delta waves in leads I, II, aVL, and V1–V6 and negative delta waves in leads in leads III and aVF. B: One episode of atrial fibrillation in the presence of an accessory pathway recorded before ablation. Black arrows indicate concomitant type 1 Brugada ECG. ECG = electrocardiogram. HeartRhythm Case Reports 2017 3, 13-17DOI: ( /j.hrcr ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

3 Figure 2 Follow-up ECGs of the proband after ablation. After radiofrequency catheter ablation, the regular ECG displays disappearance of delta waves and onset of coved-type ST-segment elevation followed by negative T waves in leads V1 and V2 in 2 days (A). One month (B) later, it shows a type 2 Brugada pattern in the fourth ICS and a typical type 1 Brugada pattern in the second ICS. A similar ECG pattern is discovered after 9 and 12 years (C & D). ECG = electrocardiogram; F-U = follow-up; ICS = intercostal space. HeartRhythm Case Reports 2017 3, 13-17DOI: ( /j.hrcr ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

4 Figure 3 Summary of the genetic information and medical history of the family. A: Family pedigree of the index case. B: Baseline ECG of proband’s youngest brother (II-7) in 4th ICS (left) and 2nd ICS (right) in 2004 who suffered from sudden cardiac death in C: DNA chromatogram of SCN5A-WT and SCN5A-R1193Q. The latter is discovered in the index case and his family member. D: Landmark events during follow-up for the family. ICS = intercostal space. HeartRhythm Case Reports 2017 3, 13-17DOI: ( /j.hrcr ) Copyright © 2016 Heart Rhythm Society Terms and Conditions

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