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The Pathogenesis of Alopecia Areata in Rodent Models

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1 The Pathogenesis of Alopecia Areata in Rodent Models
Kevin J. McElwee, Pia Freyschmidt-Paul, John P. Sundberg, Rolf Hoffmann  Journal of Investigative Dermatology Symposium Proceedings  Volume 8, Issue 1, Pages 6-11 (June 2003) DOI: /j x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Relevance of rodent models to human alopecia areata. Human alopecia areata involves considerable variation in phenotype and probably also involves genotype heterogeneity within a restricted range. An inbred rodent model may not represent all human phenotype or genotype presentations, but will be relevant to a subset of alopecia areata-affected individuals. Where a rodent model and human phenotype and genotype coincides, each rodent model represents a subset of the human population. Each rodent model may represent unique or overlappingsubsets. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 6-11DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Alopecia areata pathogenesis and perpetuation.
Journal of Investigative Dermatology Symposium Proceedings 2003 8, 6-11DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Practical and theoretical therapeutic interventions in alopecia areata pathogenesis. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 6-11DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions


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