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Aglaya G. Iyevleva, MD, PhD  Journal of Thoracic Oncology 

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1 Lung Carcinomas with EGFR Exon 19 Insertions Are Sensitive to Gefitinib Treatment 
Aglaya G. Iyevleva, MD, PhD  Journal of Thoracic Oncology  Volume 9, Issue 4, Pages e31-e33 (April 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 An example of EGFR exon 19 insertion detection. A, Hematoxylin-eosin staining of lung adenocarcinoma with EGFR ex19ins, 400× magnification. B, Electrophoretic detection of EGFR ex19ins. The fragments with insertion have larger size as compared with the normal 127 base pair band; in addition, heteroduplexes are visible in the upper part of the gel. C, DNA sequencing of the c.2213_2230dup (p.I744_K745insKIPVAI) mutation. Eighteen duplicated nucleotides are marked by a frame. WT, wild-type EGFR; INS, EGFR exon 19 insertion. Journal of Thoracic Oncology 2014 9, e31-e33DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Nucleotide and amino acid sequence of epidermal growth factor receptor insertions. Duplicated sequences are underlined, and insertions are designated by frames. Journal of Thoracic Oncology 2014 9, e31-e33DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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