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Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for.

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Presentation on theme: "Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for."— Presentation transcript:

1 Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for Extensive-Stage SCLC  Edurne Arriola, MD, PhD, Matthew Wheater, FRCP, Ian Galea, PhD, Nadia Cross, B.Med.Sci, Tom Maishman, MSc, Debbie Hamid, BAPPA, Louise Stanton, MSc, Judith Cave, FRCP, Tom Geldart, BSc, M.B.B.S., FRCP, DM, Clive Mulatero, MB, Vannessa Potter, PhD, Sarah Danson, PhD, Pennella J. Woll, FRCP, Richard Griffiths, FRCP, Luke Nolan, PhD, Christian Ottensmeier, MD, PhD  Journal of Thoracic Oncology  Volume 11, Issue 9, Pages (September 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 CONSORT diagram showing the disposition of patients in the ICE (ipilimumab, carboplatin, and etoposide) study. ITT, intention to treat. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Kaplan-Meier plots for progression-free survival (PFS) according to the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.0, (A) and immune-related response criteria (B) and according to autoantibody status at baseline (C). CI, confidence interval; irRC, immune-related response criteria; NR, not reached. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Kaplan-Meier plots for overall survival (A) and according to autoantibody status at baseline (B). OS, overall survival; CI, confidence interval. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Supplementary Figure 1 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

6 Supplementary Figure 2 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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