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Munir Boodhwani, MD, William E

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1 Safety and Efficacy of a Novel Gel for Vascular Occlusion in Off-Pump Surgery 
Munir Boodhwani, MD, William E. Cohn, MD, Jun Feng, MDPhD, Basel Ramlawi, MD, Shigetoshi Mieno, MD, Alexander Schwarz, PhD, Frank W. Sellke, MD  The Annals of Thoracic Surgery  Volume 80, Issue 6, Pages (December 2005) DOI: /j.athoracsur Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Duration of left anterior descending coronary artery (LAD) ischemia increased with increasing amounts of injected gel (Spearman r = 0.64; p = 0.02). (• = occlusion time for varying quantities of gel.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Left anterior descending coronary artery (LAD) flow. Coronary flow patterns during LAD reperfusion were similar in treatment and control groups (p = 0.51). (BL = baseline; max = maximum flow.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Regional wall motion. Regional myocardial function, as measured by percentage of segmental shortening normalized to baseline during ischemia and reperfusion, which was similar in treatment and control groups (p = 0.89). (BL = baseline; I = ischemia, Rep = reperfusion.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Microvessel reactivity was similar between treatment (dashed lines) and control (solid lines) groups in both (A) ischemic (LAD) and (B) non-ischemic (circumflex) territories to endothelium-dependent vasodilator, ADP, and endothelium independent vasodilator, SNP. Microvessel relaxation in response to endothelium-dependent vasodilator, substance P, was mildly impaired in treatment versus control groups in both ischemic and nonischemic regions (p < 0.01). (ADP = adenosine diphosphate; LAD = left anterior descending coronary artery; SNP = sodium nitroprusside.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

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