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Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas 

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Presentation on theme: "Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas "— Presentation transcript:

1 Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas  Yago Nieto, Benigno C. Valdez, Peter F. Thall, Sairah Ahmed, Roy B. Jones, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Muzaffar Qazilbash, Alison Gulbis, Paolo Anderlini, Amin Alousi, Nina Shah, Qaiser Bashir, Yan Liu, Yasuhiro Oki, Frederick Hagemeister, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Richard Champlin, Borje S. Andersson  Biology of Blood and Marrow Transplantation  Volume 21, Issue 11, Pages (November 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Event-free (EFS) and overall survival (OS) curves. (A) DLCL subgroup (n = 52). (B) HL subgroup (n = 20). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Event-free survival according to PET status at transplantation. (A) DLCL subgroup. (B) HL subgroup. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Representative cases of decrease in the level of PARP-1 in patients treated with Bu/Mel (A), Gem/Bu/Mel (B), and vorinostat/Gem/Bu/Mel (C). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

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