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Use of MicroRNA Expression Levels to Predict Outcomes in Resected Stage I Non- small Cell Lung Cancer  Eric Duncavage, MD, Boone Goodgame, MD, Ananth Sezhiyan,

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Presentation on theme: "Use of MicroRNA Expression Levels to Predict Outcomes in Resected Stage I Non- small Cell Lung Cancer  Eric Duncavage, MD, Boone Goodgame, MD, Ananth Sezhiyan,"— Presentation transcript:

1 Use of MicroRNA Expression Levels to Predict Outcomes in Resected Stage I Non- small Cell Lung Cancer  Eric Duncavage, MD, Boone Goodgame, MD, Ananth Sezhiyan, BS, Ramaswamy Govindan, MD, John Pfeifer, MD, PhD  Journal of Thoracic Oncology  Volume 5, Issue 11, Pages (November 2010) DOI: /JTO.0b013e3181f3909d Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Cases of stage I non-small cell carcinoma included predominantly squamous cell carcinomas (A) and adenocarcinomas of the lung (B) (×100 original magnification). RNA was extracted from areas of tumor that contained greater than 70% tumor nuclei and minimal necrosis. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Expression of averaged triplicate microRNA (miRNA) data normalized to rnu-6b (log plots). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Kaplan-Meier freedom-from-recurrence curves for miR-221 expression. miR-221 values were first dichotomized about a mean expression value and those cases with expression above the mean value designated “high expression” and those below designated “low expression.” Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 MiR-221 expression by recurrence status in adenocarcinoma (A) and squamous cell carcinoma (B). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 A comparison of microRNA (miRNA) expression in tumor (red) and paired, adjacent normal lung (blue) for both nonrecurrent tumors (left panel) and recurrent tumors (right panel). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

7 FIGURE 6 Expression of selected miR-221 target genes. Target gene expression was normalized to a multiplexed beta-actin control. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f3909d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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