1. Esomeprazole Versus Other Proton Pump Inhibitors in Erosive Esophagitis: A Meta- Analysis of Randomized Clinical Trials 
Ian M. Gralnek, Gareth S. Dulai, M. Brian Fennerty, Brennan M.R. Spiegel 
Clinical Gastroenterology and Hepatology 
Volume 4, Issue 12, Pages (December 2006)
DOI: /j.cgh
Copyright © 2006 AGA Institute Terms and Conditions

2. Figure 1 Results of literature search.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

3. Figure 2
Relative risk reduction forest plot (random effects model) demonstrating healing of erosive esophagitis at 4 weeks (n = 14,779).
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

4. Figure 3
Relative risk reduction forest plot (random effects model) demonstrating healing of erosive esophagitis at 8 weeks (n = 15,099).
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

5. Figure 4
Absolute risk reduction forest plot in healing of erosive esophagitis at 8 weeks (n = 15,099). ARR = 4% yielding an NNT = 25.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

6. Figure 5
NNTs for Los Angeles grades A-D. NNTs decrease as LA Grade severity of EE increases.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

7. Figure 6
GERD symptom relief at 4 weeks: esomeprazole vs comparator PPIs relative risk forest plot with fixed effects model, n = 14,996.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions

8. Figure 7
Begg’s funnel plot of studies reporting EE healing at 8 weeks selected for meta-analysis. No evidence of publication bias, P = .21 by Egger’s test, n = 15,099.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh )
Copyright © 2006 AGA Institute Terms and Conditions