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Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study Pauline A Waight, BSc, Nicholas J Andrews, PhD, Shamez N Ladhani, MD, Carmen L Sheppard, PhD, Mary P E Slack, FRCPath, Prof Elizabeth Miller, FRCPath The Lancet Infectious Diseases Volume 15, Issue 5, Pages (May 2015) DOI: /S (15) Copyright © 2015 Waight et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions
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Figure 1 Corrected* invasive pneumococcal disease incidence from epidemiological year 2000/01 to 2013/14, by serotype grouping and age PCV7=seven-valent pneumococcal conjugate vaccine. PCV13=13-valent pneumococcal conjugate vaccine. NVT=non-vaccine type. *Corrected for proportion of samples serotyped, missing age, and for the trend in total invasive pneumococcal disease up to 2009/10 (after which no trend correction was applied). The Lancet Infectious Diseases , DOI: ( /S (15) ) Copyright © 2015 Waight et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions
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Figure 2 Corrected* invasive pneumococcal disease incidence for individual serotypes grouping from epidemiological year 2000/01 to 2013/14, by age PCV7=seven-valent pneumococcal conjugate vaccine. PCV13=13-valent pneumococcal conjugate vaccine. *Corrected for proportion of samples serotyped, missing age, and for the trend in total invasive pneumococcal disease up to 2009/10 (after which no trend correction was applied). The Lancet Infectious Diseases , DOI: ( /S (15) ) Copyright © 2015 Waight et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions
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Figure 3 Number of invasive pneumococcal disease cases due to non-PCV13 serotypes in children younger than 5 years from July, 2012, to June, 2013, and from July, 2013, to June, 2014 Serotypes 15B and 15C were combined because they are considered to be one rapidly interconverting serotype. The Lancet Infectious Diseases , DOI: ( /S (15) ) Copyright © 2015 Waight et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions
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