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Daniela P. Metz, PhDa, Annette S

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1 Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease 
Daniela P. Metz, PhDa, Annette S. Bacon, FRCOphthb, Stephen Holgate, MD, DSC, FRCPc, Susan L. Lightman, PhDb,d  Journal of Allergy and Clinical Immunology  Volume 98, Issue 3, Pages (September 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 FIG. 2 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with VKC (B) stained with anti-CD3. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 FIG. 2 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with VKC (B) stained with anti-CD3. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 FIG. 4 Serial tissue sections from tarsal conjunctiva of patient with VKC showing: A, CD45RO+ cells in epithelium and subepithelium; and B, CD45RA+ cells in the same microscopic field as in A. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

11 FIG. 4 Serial tissue sections from tarsal conjunctiva of patient with VKC showing: A, CD45RO+ cells in epithelium and subepithelium; and B, CD45RA+ cells in the same microscopic field as in A. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

12 FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

13 FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

14 FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

15 FIG. 6 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with GPC (B) stained with anti-HLA-DR. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

16 FIG. 6 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with GPC (B) stained with anti-HLA-DR. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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