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Electrophysiological effects of morphine in an in vitro model of the ‘border zone’ between normal and ischaemic–reperfused guinea-pig myocardium  A. Yvon,

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Presentation on theme: "Electrophysiological effects of morphine in an in vitro model of the ‘border zone’ between normal and ischaemic–reperfused guinea-pig myocardium  A. Yvon,"— Presentation transcript:

1 Electrophysiological effects of morphine in an in vitro model of the ‘border zone’ between normal and ischaemic–reperfused guinea-pig myocardium  A. Yvon, J.-L. Hanouz, X. Terrien, P. Ducouret, R. Rouet, H. Bricard, J.-L. Gérard  British Journal of Anaesthesia  Volume 89, Issue 6, Pages (December 2002) DOI: /bja/aef283 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Effects of morphine on the incidence of conduction block and arrhythmia during simulated ischaemia (left panels) and reperfusion (right panels). Every 2 min during the ischaemic period (30 min) and the reperfusion period (30 min), values are expressed as percentages of preparations presenting conduction blocks between the two myocardial regions and spontaneous arrhythmias, defined as disturbances. Results are reported in the absence of drug (top panels) and in the presence of 0.01 μM (middle panels) and 0.1 μM morphine (bottom panels). British Journal of Anaesthesia  , DOI: ( /bja/aef283) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Effects of morphine on the incidence of loss of responsiveness to constant stimulation intensity, arrhythmias and conduction blocks during simulated ischaemia and reperfusion periods. Data are expressed as percentage of preparations with disturbances during the experiments. British Journal of Anaesthesia  , DOI: ( /bja/aef283) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions


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