1. Prohibitins Current Biology
Takashi Tatsuta, Thomas Langer 
Current Biology 
Volume 27, Issue 13, Pages R629-R631 (July 2017)
DOI: /j.cub
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2. Figure 1 Architecture and functions of prohibitins.
(A) Schematic representation of the large ring-like PHB complex composed of alternating PHB1 and PHB2 subunits in the mitochondrial inner membrane (IM). (B) Formation of PHB membrane domains containing defined proteins and membrane lipids. Upper panel: PHB complexes serving as protein scaffolds recruit membrane proteins to specific sites. They form stoichiometric complexes with the m-AAA protease, DNAJC19 and other IM proteins. Lower panel: PHB complexes serving as lipid scaffolds in the IM may define the local lipid composition and create protein-free lipid patches in the IM. (C) Versatile roles of PHB membrane domains in mitochondrial homeostasis and cellular signaling. IMS, intermembrane space; CL, cardiolipin; UPR, unfolded protein response.
Current Biology  , R629-R631DOI: ( /j.cub )
Copyright © 2017 Elsevier Ltd Terms and Conditions