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Circulating CLA+ T cells from Acute and Chronic Psoriasis Patients Manifest a Different Activation State and Correlation with Disease Severity and Extension 

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Presentation on theme: "Circulating CLA+ T cells from Acute and Chronic Psoriasis Patients Manifest a Different Activation State and Correlation with Disease Severity and Extension "— Presentation transcript:

1 Circulating CLA+ T cells from Acute and Chronic Psoriasis Patients Manifest a Different Activation State and Correlation with Disease Severity and Extension  Merce Pont-Giralt, Ana M. Giménez-Arnau, Ramon M. Pujol, Luis F. Santamaria-Babi  Journal of Investigative Dermatology  Volume 126, Issue 1, Pages (January 2006) DOI: /sj.jid Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Frequency of circulating CLA+ and CLA−CD3+HLA-DR+ subsets in various psoriasis form s and correlation with PASI and BSA. Peripheral blood mononuclear cells from the study subjects were stained with HECA-452-FITC (Pharmingen, San Diego, CA), anti-CD3-PerCP and either anti-HLA-DR, both conjugated to PE (Becton Dickinson, San Jose, CA). The same staining was performed with anti-CD4-PerCP antibody instead of anti-CD3-PerCP (Becton Dickinson, San Jose, CA). Specific staining was determined for each marker using appropriate isotype control antibodies (Becton Dickinson, San Jose, CA). Analysis was performed using a FACScalibur flow cytometer (Becton Dickinson, San Jose, CA). Values are expressed as mean±SD; *P=0.002, **P=0.0005, and ***P= Correlations of PASI and BSA with the different subpopulations are presented in the box under figure. Journal of Investigative Dermatology  , DOI: ( /sj.jid ) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Frequency of circulating CLA+ and CLA-CD4+HLA-DR+ subsets in various psoriasis forms and correlation with PASI and BSA. Values are expressed as mean±SD; ****P=0.007, *****P=0.0006, and ******P= Correlations of PASI and BSA with the different subpopulations are presented in the box under figure. Journal of Investigative Dermatology  , DOI: ( /sj.jid ) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions


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