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Volume 18, Issue 2, Pages 143-149 (April 2011)
Different responses of nitric oxide synthase inhibition on morphine-induced antinociception in male and female rats Mahmoud Hosseini, Zahra Taiarani, Mosa Al-Reza Hadjzadeh, Soodabeh Salehabadi, Maryam Tehranipour, Hojjat Allah Alaei Pathophysiology Volume 18, Issue 2, Pages (April 2011) DOI: /j.pathophys Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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Fig. 1 Comparison of basal reaction times between female and male controls, female-LN and male-LN rat groups. Data are presented as means±SEM (n=10 in each group). Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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Fig. 2 Comparison of reaction times after injection of morphine (10mg/kg) between male and female controls. Data are presented as means±SEM (n=10 in each group). 15 and 30min after injection of morphine the reaction times in male group were higher than female group. **p<0.01 compared to female group. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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Fig. 3 Comparison of reaction times after injection of morphine (10mg/kg) between female controls and female-LN group. Data are presented as means±SEM (n=10 in each group). Repeated measure ANOVA showed that the reaction times in female-LN group was higher than female controls. The animals of female-LN group were treated by l-NAME (10mg/kg/day) during 3 weeks. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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Fig. 4 Comparison of reaction times after injection of morphine (10mg/kg) between male and male-LN groups. Data are presented as means±SEM (n=10 in each group). There was no significant difference between groups. The animals of male-LN group were treated by l-NAME (10mg/kg/day) during 3 weeks. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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Fig. 5 Comparison of reaction times after injection of morphine (10mg/kg) between male-LN and female-LN groups. Data are presented as means±SEM (n=10 in each group). 45min after injection of morphine, the reaction time in female-LN group was significantly higher male-LN group. The animals of both groups were treated by l-NAME (10mg/kg/day) during 3 weeks. ***p<0.001 compared to male-LN group. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions
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