1. Patient state index vs bispectral index as measures of the electroencephalographic effects of propofol 
M Soehle, M Kuech, M Grube, S Wirz, S Kreuer, A Hoeft, J Bruhn, R.K. Ellerkmann 
British Journal of Anaesthesia 
Volume 105, Issue 2, Pages (August 2010)
DOI: /bja/aeq155
Copyright © 2010 The Author(s) Terms and Conditions

2. Fig 1
Example of the time course of the experiment: propofol was given at a constant rate during the shaded periods, resulting in plasma (Cpl) concentration (dashed green line) and effect-site (Ce) concentration (dotted pink line). The corresponding BIS values are shown as a solid blue line.
British Journal of Anaesthesia  , DOI: ( /bja/aeq155)
Copyright © 2010 The Author(s) Terms and Conditions

3. Fig 2
The relationship between the propofol effect-site concentration and PSI is shown for the ‘typical patient’ as obtained by population fit using NONMEM. The residual data of the individual patients are marked by blue circles.
British Journal of Anaesthesia  , DOI: ( /bja/aeq155)
Copyright © 2010 The Author(s) Terms and Conditions

4. Fig 3
The response of the BIS to changes in the propofol effect-site concentration is displayed for the ‘typical patient’ as revealed by population fit using the NONMEM software. The blue triangles indicate the residual data of the individual patients.
British Journal of Anaesthesia  , DOI: ( /bja/aeq155)
Copyright © 2010 The Author(s) Terms and Conditions

5. Fig 4
For the recommended ranges (shown as bars on the left and right ordinate) of the PSI (25–50) and the BIS (40–60), the corresponding propofol effect-site concentration site ranges (displayed as bars on the abscissa) are shown. The relation is based on the pharmacodynamic effect of propofol on BIS (blue line) and PSI (dotted green line) for the ‘typical patient’ as revealed by NONMEM.
British Journal of Anaesthesia  , DOI: ( /bja/aeq155)
Copyright © 2010 The Author(s) Terms and Conditions