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Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women  Eydie L Moses-Kolko,

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Presentation on theme: "Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women  Eydie L Moses-Kolko,"— Presentation transcript:

1 Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women  Eydie L Moses-Kolko, M.D., Sarah L Berga, M.D., Phil J Greer, M.S., Gwenn Smith, Ph.D., Carolyn Cidis Meltzer, M.D., Wayne C Drevets, M.D.  Fertility and Sterility  Volume 80, Issue 3, Pages (September 2003) DOI: /S (03)

2 FIGURE 1 Regions where 5HT2A receptor BP increased following E2 and combined E2 + P4 administration. Significant 5HT2A receptor BP increases [voxel threshold of P(uncorrected)<.01] are superimposed onto MRI image sections that have been spatially transformed to the Montreal Neurological Institute template. Coronal sections through the mesiotemporal, ventrolateral prefrontal, and anterior cingulate cortices are displayed. (Row A), 5HT2A receptor BP increases following E2 alone relative to the baseline condition. (Row B), 5HT2A receptor BP increases for the contrast of combined E2 + P4 relative to baseline. (Row C), Post hoc exploration of 5HT2A receptor BP increases following E2 alone at the less conservative, P(uncorrected)<.05. Moses-Kolko. 5HT2A receptor increases after HT. Fertil Steril 2003. Fertility and Sterility  , DOI: ( /S (03) )

3 FIGURE 2 Mean ratios of the unmetabolized [18F]altanserin to total radioactivity concentration (with standard deviation bars) in plasma at 2, 10, 30, 60, and 90 minutes post-[18F]altanserin injection. E2 = estradiol; P4 = progesterone. Moses-Kolko. 5HT2A receptor increases after HT. Fertil Steril 2003. Fertility and Sterility  , DOI: ( /S (03) )

4 FIGURE 3 Scatterplots showing lack of correlation between 5HT2A receptor binding potential and proportion of unmetabolized [18F]altanserin in plasma at 60 minutes post [18F]altanserin injection. Moses-Kolko. 5HT2A receptor increases after HT. Fertil Steril 2003. Fertility and Sterility  , DOI: ( /S (03) )


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