1. Opening Activity: pd 1 April 22, 2019
Have your Bioflower Questions out for a stamp.
Review your labs, readings and notes for:
Homeostasis
Protein -> Trait
Modeling Proteins
I can… Explain the relationship between DNA, proteins, traits.
Homework:
Gene Regulation Reading and Cell #1 and Cell #2

2. Period 1 Gene Regulation Quiz
Use the handout “Molecular Pathway for Coat Color” to help answer questions #2 and #3.
When you are done quizzing…
Turn into folder in front of classroom.
Complete the following in your journal:
Draw a nucleus of a cell that would have two of the SAME alleles? What type of proteins would be produced?
Draw a nucleus of a cell that would have two DIFFERENT alleles? What type of proteins would be produced?
3. Pick up HW and complete: Gene Regulation Reading and Complete Activity for Cell #2 and #3.

3. Opening Activity: pd 2-4 April 22, 2019
Have your Bioflower Questions out for a stamp.
Collect a whiteboard/pen to draw the following:
Draw a nucleus of a cell that would have two of the SAME alleles? What type of proteins would be produced?
Draw a nucleus of a cell that would have two DIFFERENT alleles? What type of proteins would be produced?
I can… Explain the relationship between DNA, proteins, traits.
Homework:
Gene Regulation Reading and Cell #1 and Cell #2

4. Bioflower Type 1: Two functional alleles
= nonfunctional
1 from mom
2 mom
1 from dad
2 dad
nucleus
BOTH ALLELES ARE EXPRESSED!

5. Bioflower Type 2: One functional allele and one nonfunctional allele
nucleus
BOTH ALLELES ARE EXPRESSED!

6. Bioflower Type 3: Two nonfunctional alleles
nucleus
BOTH ALLELES ARE EXPRESSED!

7. functional, functional
The combination of alleles determines the observed trait (characteristics)
functional
allele
functional
allele
non-functional allele
functional
allele
non-functional allele
Chromosome
combination
non-functional allele
Allele
combination
functional, functional
functional,
nonfunctional
nonfunctional,
nonfunctional
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

8. The combination of alleles determines the observed characteristics
Phenotype – the observed (or measurable) trait of an organism that relates to one gene
Genotype – the two alleles that an organism has for a trait = the combination of alleles
Example: Trait = “flower color”
Phenotype = “RED” or “BLUE”
Genotype = “Functional / Functional” or “Functional / Nonfunctional” or “Nonfunctional /Nonfunctional”

9. functional, functional
The combination of alleles determines the observed trait (characteristics)
functional
allele
functional
allele
non-functional allele
non-functionalallele
functional
allele
non-functional allele
Chromosome
combination
GENOTYPE
functional, functional
functional,
nonfunctional
nonfunctional,
nonfunctional
Which combinations produce red?
Which combinations produce blue?
PHENOTYPE
RED
RED
BLUE

10. Bioflower Questions Review – pd 2 & 4
Create a Whiteboard with your answers to share with the class (6-8 min)
Table 1 - #1 and 5i
Table 2 - #2 and 5a/b
Table 3 - #3 and 5 c/d
Table 4 - #4 and 5 e/f
Table 5 - #1 and 5i
Table 6 - #2 and 5g/h
Table 7 - #6
Table 8 - #6
2. Share whiteboards, discuss accuracy and ask questions

11. Bioflower Questions Review – pd 3
Create a Whiteboard with your answers to share with the class (6-8 min)
Table 1 - #1 and 5i
Table 2 - #2 and 5a/b
Table 3 - #3 and 5 c/d
Table 6 - #4 and 5 e/f
Table 7 - #6
Table 8 - #6
Share whiteboards, discuss accuracy and ask questions

12. Learning Tracking Tool
Fill out next row:
Cereal(Froot Loops) and Bioflower Proteins
We will review tomorrow in class.

13. Homework – Due 4/23 5.1 Gene Regulation Reading and Practice
Read front page GENE Regulation. Highlight key terms.
Read through the back side and complete the activity for cell #2 and cell #3

14. Opening Activity: April 19, 2019
Correction!!! Pigments are NOT proteins, they are fats – review question #3 from bioflowers – what were the proteins involved?
Pick up handout at front table – tape in!!
Label the blanks with the following vocab:
Regulatory protein, Regulatory Region & Coding Region
I can…Explain how genes are turned on/off to maintain homeostasis.
Homework:
Kindness Observations-4/24
Revisit Initial Models

15. How can cells have the same DNA but different sets of proteins?
Gene expression refers to the genes being translated into proteins in a cell
In a given cell, some genes are “on” while other genes are “off”. Different cells express different sets of genes.

16. How are Genes Regulated?
Coding region – the part of the DNA with specific information to build a protein
Regulatory region – sequence of DNA that can be bound by a protein to regulate gene expression
Regulatory protein that binds to to in order to turn transcription on or off
Indicate where the regulatory DNA is compared to the coding sequence.

17. How are Genes Regulated?
Coding region – the part of the DNA with specific information to build a protein
Regulatory region – sequence of DNA that can be bound by a protein to regulate gene expression
Regulatory protein that binds to to in order to turn transcription on or off
Indicate where the regulatory DNA is compared to the coding sequence.
Regulatory Protein
Regulatory Region
Coding Sequence

18. How are Regulatory Proteins Turned On?
Regulatory proteins are turned ON or OFF by signals detected by the cell
Signals can be…
Hormones
Sunlight
Food
???
Indicate where the regulatory DNA is compared to the coding sequence.
Regulatory Protein
Regulatory Region
Coding Sequence

19. Today’s Work
Complete the Gene Regulation Activity in your journal for a STAMP.
Complete new row in LTT called Gene Regulation
Pick up C. Elegans handout – complete front side only.
Regulatory
Protein
Regulatory DNA Sequence
AGATCAGC
TCTAGTCG
CGACTCAC
GCTGAGTG
TAGACTCC
ATCTGAGG
GAGCTACG
CTCGATGC
ATGCCTGC
TACGGACG
CELL #1
Regulatory proteins in cell
Which proteins are made?
gene C is transcribed, RNA is translated, protein C is made
GAGCTACG
CTCGATGC
AGATCAGC
TCTAGTCG
ATGCCTGC
TACGGACG
Protein C
Coding sequence gene A
Coding sequence gene B
Coding sequence gene C

20. Opening Activity: April 24, 2019
Pick up your quiz from last week.
Triple stamps today!
Gene Regulation Handout
Gene Regulation LTT
Kindness Journal
3. Pick up a C. Elegans Handout at front table - complete the front side.
I can… Explain how genes are turned on/off to maintain homeostasis.
Homework:
Review Initial Model and Make at least 3 changes or additions

21. How do worms recover from environmental changes?
Round 1 – for 3 minutes share organism scale.
Round 2 – for 3 minutes share cellular scale
Round 3 – for 3 minutes share molecular scale.
Important: Each group member will have a chance to speak. Record your new ideas or changes on your paper.

22. Slow, LOTS of egg, moving a bit more but still sluggish.
Class Data Table – Period 2 (eggs, larvae and adults and worms response to touch)
HIGH Salt
Day 1
(after 15 min)
Curled up, not moving, hard to see worms, hardly any eggs in some/several eggs in other agar plates, sluggish movement
Day 2
(after 24 hours)
Slow, LOTS of egg, moving a bit more but still sluggish.
Day 3 (after 48 hours)
Normal S-shaped movement, lots of life stages

23. Human Skin Color – No Albinism
Colorless Molecule
Melanin Pigment Molecule
Functional Tyrosinase
Protein
When the protein is a functional shape, we see a particular trait
 The skin has pigment

24. Back to Initial Ideas.. Why do people tan?
Homework: Review your ideas from 3 weeks ago. In a different color add new ideas to help explain why people tan.
Tomorrow -Model Revision Sheet: Identify 3 parts of your initial ideas that changed, explain why and provided evidence.

25. Opening Activity: April 24, 2019
Have your C. Elegans Explanation out. Notice on molecular scale:
There are two parts of a gene, what are the two parts?
What gene was turned on in the worms?
In 1-2 sentences, explain what happened to the worm at a molecular scale.
GENE REGULATION TEST IS TOMORROW – 4/26
(Key Ideas: DNA->Protein->Trait and Gene Regulation)
I can… Explain our final model - why skin darkens in sunlight.
Homework:
Review your LTT, Review Vocabulary, STUDY!!!

26. Back to Initial Ideas.. Why do people tan?
Review your ideas from 3 weeks ago. In a different color add new ideas to help explain why people tan.
Model Revision Sheet: Identify 3 parts of your initial ideas that changed, explain why and provided evidence.
Group Work: Create a whiteboard to show your final explanation.
Video: Add new ideas.
Group Spy- Select a group member to visit other groups to review their board, listen in, etc. come back to group to add new ideas.
More Practice: If group is done, pick up a “Sample Assessment” from front of room and complete in groups of TWO.