1. TMMOD: An improved hidden Markov model for predicting transmembrane topology (Bioinformatics 2005)

2. Mod.
Reg.
Data
set
Correct
topology
location
Sens-
itivity
Speci-
ficity
TMMOD 1
(a)
(b)
(c)
S-83
65 (78.3%)
51 (61.4%)
64 (77.1%)
67 (80.7%)
52 (62.7%)
97.4%
71.3%
97.1%
TMMOD 2
61 (73.5%)
54 (65.1%)
66 (79.5%)
99.4%
93.8%
99.7%
TMMOD 3
70 (84.3%)
74 (89.2%)
71 (85.5%)
98.2%
95.3%
99.1%
TMHMM
69 (83.1%)
96.2%
PHDtm
(85.5%)
(88.0%)
98.8%
95.2%
S-160
117 (73.1%)
(57.5%)
128 (80.0%)
103 (64.4%)
126 (78.8%)
77.4%
96.1%
97.0%
80.8%
96.7%
120 (75.0%)
(60.6%)
118 (73.8%)
132 (82.5%)
121 (75.6%)
135 (84.4%)
98.4%
97.7%
97.2%
95.6%
110 (68.8%)
135 (84.4%)
133 (83.1%)
124 (77.5%)
143 (89.4%)
97.8%
94.5%
98.3%
97.6%
98.1%
123 (76.9%)
134 (83.8%)

7. Fitness value:

11. L. Petersen et al, (2003), J. Mol. Biol. 326:1361-1372.

18. BMC Bioinformatics, 2007.