1. Ulcerative Colitis Definition
It is a recurrent ulcerative and inflammatory disease of the mucosal layer of the colon and rectum.
It is a serious disease systemic complications high mortality rate
Incidence
Peak – 30 to 50 years of age
Pathophysiology
Affects the superficial mucosa of the colon multiple ulcerations

2. Diffuse inflammation, desquamation of the colonic epithelium
Ulcers may bleed
Lesions are continuous
Disease begins in the rectum and may involve the entire colon
The bowel narrows shortens and thickens because of muscular hypertrophy and fat deposits
The inflammation may spread into the muscularis, inhibiting its ability to contract  toxic megacolon  distension of the colon

3. Colonoscopic view – ulcerative colitis lesions

5. Mucosal thickening and shortening of the whole colon – Barium enema X-ray

6. Specimen after colectomy

7. Clinical manifestations
Exacerbations and remissions
Anorexia,
Fever,
Vomiting, Weight loss
Abdominal pain
Urgent need to defaecate
Diarrhoea
Intermittent tenesmus
Passage of 10 – 20 liquid stools a day
Rectal bleeding
Dehydration
Rebound tenderness RIF
Skin lesions (erythema nodosum), eye lesions (uveitis), joint abnormalities (arthritis) and liver disease
Hypocalcaemia, anaemia

8. Investigations
Hb – may be low
TC – raised
ESR – raised
Albumin level – low
Electrolyte imbalance +
Sigmoidoscopy
Barium enema
Mucosal inflammation, friability, exudate and ulcerations

9. Normal and abnormal colonoscopic appearance

10. Double contrast study of the colon – Barium and air

11. Caution to nurses
In acute ulcerative colitis no enema –(especially cathartics) - perforation may occur
If any preparation is necessary at all, give liquid diet for a few days and then a gentle tap water enema on the day of the investigation may be done

12. complications
Toxic megacolon
Perforation – high mortality
Bleeding as a result of ulceration
Highly vascular granulation tissue  pseudo polyps

14. Gas under right diaphragm – a sign in X-ray chest indicating pneumoperitoneum – Perforation of the intestine

15. Management Medical treatment Suppress inappropriate immune responses
Reduce inflammation
Provide rest to the diseased bowel
Nutritional therapy

16. Nutritional therapy
Oral fluids
Low residue, high -protein, high calorie diet
Vitamin supplements
Iron replacement
Correction of fluid and electrolyte imbalance by IV fluids
Avoid milk
Avoid cold foods and smoking
Total parental nutrition may be needed

17. Pharamacologic Therapy
Sedatives
Antidiarrhoeals
Antiperistaltic drugs
Sulphonamides such as sulfasalazine, sulfisoxazole
Antibiotics for infection like abscesses, perforations, peritonitis
Parenteral adrenocorticotropic hormone (ACTH)
Beware of complications.
New topical and oral aminosalicylates (e.g.mesalamine, olsalazine are very effective in treatment.)
Immunosuppressants used to reduce the dosage of corticoids and to prevent recurrences.

18. Surgical Treatment
Strictureplasty
Resection and anastomosis
Segmental colectomy with anastomosis
b) Total colectomy and ileostomy