1. Volume 67, Issue 5, Pages 1114-1115 (November 2017)
Serum metabolic signatures in patients with overt hepatic encephalopathy 
Sven Stengel, Andreas Stallmach, Klaus Richter, Andreas Landrock, Jochen Hampe, Tony Bruns 
Journal of Hepatology 
Volume 67, Issue 5, Pages (November 2017)
DOI: /j.jhep
Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

2. Fig. 1
Analysis of patient characteristics and metabolome. A) Patient characteristics. Data are given as median (range) or numbers (percentage). B) Principal component analysis (PCA) was performed on serum metabolome data encompassing metabolites passing QC criteria (n=639) for patients with decompensated cirrhosis and ascites without OHE (red), acute infection-related OHE (blue), and acute OHE precipitated by other factors (green). Patient-specific metabolomes were plotted against principal components 1 and 2 and ellipses represent 90% of group variability. C) Partial least squares discriminant analysis (PLS-DA) was performed to discriminate between the three patient groups as indicated above. PLS-DA scores 1 and 2 were plotted and 90% of group variability was denoted by group specific ellipses. D) Mann-Whitney U-Test was performed comparing patients with and without OHE identifying metabolites with significant differences in metabolite expression. The metabolite expression pattern was illustrated using hierarchical clustering of patients and metabolites followed by heat map plotting of metabolite expression data. Identified methylated compounds of metabolites of endogenous origin are indicated and compounds derived from ammonia are highlighted in red (FAME: fatty acid methyl esters).
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2017 European Association for the Study of the Liver Terms and Conditions