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Volume 63, Issue 5, Pages (May 2003)

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1 Volume 63, Issue 5, Pages 1809-1816 (May 2003)
Histomorphometric features of bone in patients with primary and secondary hypoparathyroidism  Yoshifumi Ubara, Tomohisa Fushimi, Tetsuo Tagami, Naoki Sawa, Junichi Hoshino, Masafumi Yokota, Hideyuki Katori, Fumi Takemoto, Shigeko Hara  Kidney International  Volume 63, Issue 5, Pages (May 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 Light microscopic examination of the two cases showed normal bone volume in case 1 (A), and markedly increased bone volume in case 2 (B). Light microscopic examination of case 3 (C) also showed normal bone volume in comparison with age- and gender-matched controls. However, bone trabecular connectivity was poor, and island bone was rather prominent. (A) Villanueva staining, original magnification ×40; (B) original magnification ×40; (C) original magnification ×40. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 Polarizing microscopy indicated normal lamellar cancellous bone in case 1 (A) and case 2 (B), and case 3 (C) showed that most of the cancellous bone had lamellar structure, while woven bone was visible only in small areas. (A), (B), and (C) original magnification ×40. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 A small number of hump-like structures (arrows) protrude from the quiescent surface of trabecular bone, a pattern which has been called “minimodeling” in case 1 (A) and case 2 (B). Hump-like bone formations (arrows) representing minimodeling sites were evident in case 3 (C, D). (A) Villanueva staining ×100; (B) Villanueva staining ×200; (C) Villanueva staining ×100; (D) polarizing microscopy ×100. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

5 Figure 3 A small number of hump-like structures (arrows) protrude from the quiescent surface of trabecular bone, a pattern which has been called “minimodeling” in case 1 (A) and case 2 (B). Hump-like bone formations (arrows) representing minimodeling sites were evident in case 3 (C, D). (A) Villanueva staining ×100; (B) Villanueva staining ×200; (C) Villanueva staining ×100; (D) polarizing microscopy ×100. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

6 Figure 4 Fluorescence microscopy did not show labeling by tetracycline at most trabecular bone surfaces. Focally, tetracycline labeling was observed in only a small area (white arrows) within trabecular bone in case 1 (A) (magnification ×100), and in a region of minimodeling (white arrows) of the trabecular bone surface in case 2 (B) (magnification ×200). Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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