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In vitro effects of antihypertensive drugs on thromboxane agonist (U46619)-induced vasoconstriction in human internal mammary artery  Tanaka K.A. , Szlam.

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Presentation on theme: "In vitro effects of antihypertensive drugs on thromboxane agonist (U46619)-induced vasoconstriction in human internal mammary artery  Tanaka K.A. , Szlam."— Presentation transcript:

1 In vitro effects of antihypertensive drugs on thromboxane agonist (U46619)-induced vasoconstriction in human internal mammary artery  Tanaka K.A. , Szlam F. , Katori N. , Tsuda A. , Levy J.H.   British Journal of Anaesthesia  Volume 93, Issue 2, Pages (August 2004) DOI: /bja/aeh189 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Concentration–response curves for nitroglycerin (n=6), nitroprusside (n=6), and nicardipine (n=7) in human IMA contracted with the TxA2 analogue U Data are expressed as mean (sd), n=number of vessel segments. M=concentration of drugs in mol litre−1. British Journal of Anaesthesia  , DOI: ( /bja/aeh189) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Concentration–response curves for fenoldopam (n=6) and nicorandil (n=6) in human IMA contracted with the TxA2 analogue U The curve for SNP was also shown as a reference. Data are expressed as mean (sd), n=number of vessel segments. M=concentration of drugs in mol litre−1. British Journal of Anaesthesia  , DOI: ( /bja/aeh189) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Concentration–response curves for adenosine (n=6) and hydralazine (n=6) in human IMA contracted with the TxA2 analogue U The curve for SNP was also shown as a reference. Data are expressed as mean (sd), n=number of vessel segments. M=concentration of drugs in mol litre−1. British Journal of Anaesthesia  , DOI: ( /bja/aeh189) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Concentration–response curves for labetalol (n=6), enalaprilat (n=6), and SNP (n=6, reference) in human IMA contracted with the TxA2 analogue U Relaxation response to labetalol (n=5) in human IMA contracted with norepinephrine was also shown (Labetalol-NE). Data are expressed as mean (sd), n=number of vessel segments. M=concentration of drugs in mol litre−1. British Journal of Anaesthesia  , DOI: ( /bja/aeh189) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions


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