1. Figure 1. T-cell lymphoma–free survival of untreated and IR-exposed Mlh1−/− mice. Kaplan–Meier survival ...
Figure 1. T-cell lymphoma–free survival of untreated and IR-exposed Mlh1^−/− mice. Kaplan–Meier survival curves for Mlh1^−/− mice. The Mlh1^−/− mice were left untreated or irradiated with 2 Gy of X-rays at 2 or 10 weeks of age. Causes of death other than T-cell lymphoma are marked with crosses.
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Carcinogenesis, Volume 40, Issue 2, 04 February 2019, Pages 216–224,
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2. Figure 2. Mutational landscape of spontaneous and IR-associated T-cell lymphomas in Mlh1−/− mice identified ...
Figure 2. Mutational landscape of spontaneous and IR-associated T-cell lymphomas in Mlh1^−/− mice identified by whole-exome sequencing. (A) The numbers of single-nucleotide variants (SNVs) and InDels per samples. (B) Frequency of mutations according to the type of base substitution. (C) Number and types of InDels per samples. The samples are sorted based on the number of mutations. del, deletion; ins, insertion.
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Carcinogenesis, Volume 40, Issue 2, 04 February 2019, Pages 216–224,
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3. Figure 3. Contribution of the COSMIC signatures to individual T-cell lymphomas of Mlh1−/− mice. Heatmap with ...
Figure 3. Contribution of the COSMIC signatures to individual T-cell lymphomas of Mlh1^−/− mice. Heatmap with the cosine similarity between the mutational profile of each T-cell lymphomas and its COSMIC signatures. The 30 signatures are ordered according to hierarchical clustering (average linkage) using the cosine similarity between signatures, such that similar signatures are displayed close together. The COSMIC signatures 6, 15 and 20 are shown in bold type to denote their association with MMR deficiency. The difference in the mutational profiles between one of the spontaneous lymphomas (case no. 4) and the other cases reflects the extremely small number of mutations identified in the lymphoma of case no. 4. Sig, signature.
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Carcinogenesis, Volume 40, Issue 2, 04 February 2019, Pages 216–224,
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4. Figure 4. Mutational target genes in spontaneous and IR-associated T-cell lymphomas in Mlh1−/− mice ...
Figure 4. Mutational target genes in spontaneous and IR-associated T-cell lymphomas in Mlh1^−/− mice identified by whole-exome sequencing. Shown are the coding-sequence mutations within the 30 genes that were frequently identified in the lymphomas. The mutated genes were sorted based on functional categories. q-values for the significance of the identified mutations on each gene are shown. The top and right bar charts show the number of coding-sequence mutations and percentage of samples containing a mutation, respectively. The samples are arranged in the same order as in Figure 2.
Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press. All rights reserved. For Permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (
Carcinogenesis, Volume 40, Issue 2, 04 February 2019, Pages 216–224,
The content of this slide may be subject to copyright: please see the slide notes for details.