1. Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine
Kevin R. Campos
J. Am. Chem. Soc. 2006, 128,

2. 2-Arylpyrrolidines Biologically active compounds as
neuronal nicotinic acetylcholine
receptor.
Effective controllers in asymmetric
synthesis.

9. Conclusions
The enantioselective deprotonation/transmetalation/Negishi coupling was found to be quite general, affording a diverse array of 2-arylpyrrolidines in good yield and 96:4 er.
This sequence offers a number of advantages over existing methods and represents the most convenient and practical synthesis of enantiomerically enriched 2-arylpyrrolidines and 2,5-diarylpyrrolidines.