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Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

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1 Cardiomyocytes Replicate and their Numbers Increase in Young Hearts
Nawazish Naqvi, Reena Singh, Siiri E. Iismaa, Ming Li, John W. Calvert, David I.K. Martin, Richard P. Harvey, Robert M. Graham, Ahsan Husain  Cell  Volume 163, Issue 4, Pages (November 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Verifying CM Mitoses in P15 Mouse Cardiac Left Ventricle by an Independent Laboratory from Blinded Histological Heart Samples (A and B) Immunohistochemical identification of mitotic CMs (red staining, Aurora B-positive cells) in transverse cut tissue sections showing localization in the left ventricle (LV) of P15 mice (B), with no Aurora B-positive cells evident in the LV of the P10 heart (A). CMs are labeled with cardiac troponin T (cTNT) (green) and nuclei are labeled with DAPI (blue). Arrows show some Aurora B-positive CMs. Experimental procedures used for immunohistochemistry were essentially as described (Naqvi et al., 2014). The Aurora B antibody (Abcam, ab 2254), supplied as a 1-mg/ml solution, was used at a dilution of 1:50. Sections were prepared and antibodies provided by the Graham laboratory. Immunohistochemical staining was performed in a blinded manner by the Harvey laboratory. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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