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Ari Karason, Johann E. Gudjonsson, Ruchi Upmanyu, Arna A

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Presentation on theme: "Ari Karason, Johann E. Gudjonsson, Ruchi Upmanyu, Arna A"— Presentation transcript:

1 A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting 
Ari Karason, Johann E. Gudjonsson, Ruchi Upmanyu, Arna A. Antonsdottir, Valdimar B. Hauksson, E. Hjaltey Runasdottir, Hjortur H. Jonsson, Daniel F. Gudbjartsson, Michael L. Frigge, Augustine Kong, Kari Stefansson, Helgi Valdimarsson, Jeffrey R. Gulcher  The American Journal of Human Genetics  Volume 72, Issue 1, Pages (January 2003) DOI: /345646 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Genome scan of 39 families with PsA with 1,000-microsatellite framework marker set, in addition to the fine mapping markers in all locations of interest. The multipoint LOD score is shown on the vertical axis; the distance from the p-terminal end of the chromosome (in cM) is shown on the horizontal axis. The American Journal of Human Genetics  , DOI: ( /345646) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Linkage result of 39 families on chromosome 16 with additional markers and considering paternal transmissions only (black line) and maternal transmissions only (red line). The multipoint LOD score is shown on the vertical axis; the distance from the p-terminal end of the chromosome (in cM) is shown on the horizontal axis. The American Journal of Human Genetics  , DOI: ( /345646) Copyright © 2003 The American Society of Human Genetics Terms and Conditions


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