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Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity  Thomas W. Wakefield, M.D., Walter.

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Presentation on theme: "Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity  Thomas W. Wakefield, M.D., Walter."— Presentation transcript:

1 Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity  Thomas W. Wakefield, M.D., Walter M. Whitehouse, M.D., James C. Stanley, M.D.  Journal of Vascular Surgery  Volume 1, Issue 2, Pages (March 1984) DOI: / (84) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Mean arterial blood pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Cardiac output response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Superior mesenteric artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Femoral artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 Femoral artery resistance changes in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 6 Portal venous pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

8 Fig. 7 Pulmonary capillary wedge pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

9 Fig. 8 Pulmonary vascular resistance changes in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

10 Fig. 9 Coronary artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

11 Fig. 10 Changes in total peripheral resistance in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

12 Fig. 11 Mean arterial blood pressure changes in response to rapid intravenous administration of protamine sulfate with and without protamine sulfate pretreatment (0.75 mg/kg) prior to heparinization (groups II and III). Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

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