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H2S to Mitigate Vascular Aging: A SIRT1 Connection

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Presentation on theme: "H2S to Mitigate Vascular Aging: A SIRT1 Connection"— Presentation transcript:

1 H2S to Mitigate Vascular Aging: A SIRT1 Connection
Thiruma V. Arumugam, Brian K. Kennedy  Cell  Volume 173, Issue 1, Pages 8-10 (March 2018) DOI: /j.cell Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 Mechanisms by which Exogenous H2S and Nutrient Restriction Reverse Vascular Aging Nutrient deprivation (M&C) increases VEGF via the amino-acid-sensing eIF2α kinase GCN2 and the transcription factor ATF4. GCN2/ATF4 activation increases CGL expression and H2S production. H2S boosts glucose uptake and glycolysis. Exogenous H2S promotes NAD+/SIRT1-dependent VEGF production. Collectively, this leads to EC proliferation, migration, and angiogenesis, as well as reversal of vascular aging. Of note, the link between intracellular H2S production and its action in other cells in an exogenous manner is unknown at the moment. Cell  , 8-10DOI: ( /j.cell ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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