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Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting:

Published byΤάκης Βασιλειάδης Modified over 5 years ago

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Presentation on theme: "Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting:"— Presentation transcript:

1 Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study  Robert M. Mentzer, MD, Claus Bartels, MD, Roberto Bolli, MD, Steven Boyce, MD, Gerald D. Buckberg, MD, Bernard Chaitman, MD, Axel Haverich, MD, John Knight, MD, Philippe Menasché, MD, M. Lee Myers, MD, Jose Nicolau, MD, Maarten Simoons, MD, Lars Thulin, MD, Richard D. Weisel, MD  The Annals of Thoracic Surgery  Volume 85, Issue 4, Pages (April 2008) DOI: /j.athoracsur Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Proportion of patients experiencing the composite endpoint of death or nonfatal myocardial infarction (MI) in the placebo group (white bars [n = 2,891]) and cariporide-treated group (black bars [n = 2,870]). The EXPEDITION trial achieved primary endpoint by demonstrating a significant reduction in the incidence of death or nonfatal MI after coronary artery bypass graft surgery. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Time to death or nonfatal myocardial infarction (MI) in the placebo and cariporide groups. The divergence in the postoperative incidence of death/nonfatal MI occurred primarily within the first 3 days of treatment. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Cariporide treatment and incidence of nonfatal myocardial infarction (MI) after coronary artery bypass graft surgery. (White bars = placebo [n = 2,891]; black bars = cariporide-treated group [n = 2,870]). Inhibition of the sodium hydrogen exchanger (NHE) was associated with a markedly significant reduction in MI after coronary artery bypass graft surgery. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Cariporide treatment and effect on mortality after coronary artery bypass graft surgery. (White bars = placebo [n = 2,891]; black bars = cariporide-treated group [n = 2,870]). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

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