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Pushing and Pulling: Microtubules Mediate Meiotic Pairing and Synapsis

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Presentation on theme: "Pushing and Pulling: Microtubules Mediate Meiotic Pairing and Synapsis"— Presentation transcript:

1 Pushing and Pulling: Microtubules Mediate Meiotic Pairing and Synapsis
Sue L. Jaspersen, R. Scott Hawley  Cell  Volume 139, Issue 5, Pages (November 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 SUN/KASH Proteins Function in Pairing and Synapsis
A bridge across the nuclear membrane is formed by the KASH protein ZYG-12 and the protein SUN-1. ZYG-12 directly interacts with dynein, which can walk along microtubules in the cytoplasm. Because of this connection through the nuclear envelope, the energy of microtubule movement is transmitted to chromosomes, which are attached to SUN-1 via their pairing centers. Binding of pairing center proteins, such as ZIM1-3 or HIM-8, to SUN-1 is probably indirect and may require either a meiosis-specific phosphorylation of SUN-1 or an unidentified membrane-associated protein. The formation of pairing center/SUN-1/ZYG-12 patches may involve oligomerization of SUN-1 and ZYG-12. Completion of the patch leads to the pairing of homologous chromosomes, a prerequisite for synapsis along the length of the chromosomes. Cell  , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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