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Contractions in human coronary bypass vessels stimulated by extracellular nucleotides  Catharina Borna, MD, Lingwei Wang, MD, Tomas Gudbjartsson, MD, Lena.

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Presentation on theme: "Contractions in human coronary bypass vessels stimulated by extracellular nucleotides  Catharina Borna, MD, Lingwei Wang, MD, Tomas Gudbjartsson, MD, Lena."— Presentation transcript:

1 Contractions in human coronary bypass vessels stimulated by extracellular nucleotides 
Catharina Borna, MD, Lingwei Wang, MD, Tomas Gudbjartsson, MD, Lena Karlsson, MD, PhD, Sverker Jern, MD, PhD, Malin Malmsjö, MD, PhD, David Erlinge, MD, PhD  The Annals of Thoracic Surgery  Volume 76, Issue 1, Pages (July 2003) DOI: /S (03)

2 Fig 1 (A) Concentration-dependent contractions to αβ-MeATP (αβ-methylene-adenosine triphosphate) in saphenous vein (solid circles) and internal mammary artery (open circles). (B) Concentration-dependent contractions to UDPβS (uridine 5’-O-thiodiphosphate) in saphenous vein (solid circles) and internal mammary artery (open circles). The UDPβS was added after desensitization of P2X1-receptors with αβ-MeATP (10−5 M). (C) Concentration-dependent contractions to UTPγS (uridine 5’-O-3-thiotriphosphate) in saphenous vein (solid circles) and internal mammary artery (open circles). The UTPγS was added after desensitization of P2X1-receptors with αβ-MeATP (10−5 M). Contractions are expressed as percentage of an initial contraction induced by 60 mmol/L K+. Data are shown as mean ± SEM of 6 or 7 patients. The Annals of Thoracic Surgery  , 50-57DOI: ( /S (03) )

3 Fig 2 Representative example of contractions induced by single doses of αβ-MeATP (αβ-methylene-adenosine triphosphate), UTPγS (uridine 5’-O-3-thiotriphosphate), and UDPβS (uridine 5’-O-thiodiphosphate). The UTPγS, and UDPβS were added after desensitization of P2X1-receptors with αβ-MeATP (10−5 M). Contractions are expressed as percentage of an initial contraction induced by 60 mmol/L K+. The Annals of Thoracic Surgery  , 50-57DOI: ( /S (03) )

4 Fig 3 Representative example of contraction induced by single dose of adenosine triphosphate (ATP) after desensitization of P2X1 receptors and P2Y2/4 receptors. The P2X1 receptors were desensitized with αβ-MeATP ([αβ-methylene-adenosine triphosphate] 10−5 M) and the P2Y2/4 receptors were desensitized with UTPγS ([uridine 5’-O-3-thiotriphosphate] 10-4 M). Contractions are expressed as percentage of an initial contraction induced by 60 mmol/L K+. The Annals of Thoracic Surgery  , 50-57DOI: ( /S (03) )

5 Fig 4 The mRNA expression profiles of P2 receptors in saphenous vein (open bars) and internal mammary artery (solid bars). Data are shown as the ratios of targets/GAPDH (glyceraldehyde-3phosphate dehydrogenase; see methods) and the mean values are given over each column. *p less than 0.05 versus other target genes in each tissue. The Annals of Thoracic Surgery  , 50-57DOI: ( /S (03) )

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