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CED-1 is a protein that localizes to the plasma membrane

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Presentation on theme: "CED-1 is a protein that localizes to the plasma membrane"— Presentation transcript:

1 CED-1 is a protein that localizes to the plasma membrane
that affects engulfment of dead cells that acts in engulfing cells that recognizes apoptotic cells All of the above

2 What is the evidence for CED-1 acting in engulfing cells?
Genetic mosaic analysis Double mutant analysis Its molecular identity as a membrane protein CED-1::GFP clusters around apoptotic cells Comparison of the rescuing activity of CED-1 when expressed in dying cells or engulfing cells in the ced-1(lf) mutants

3 CED-1::GFP clustering around apoptotic cells depends on
CED-1 interaction with CED-7 CED-1 interaction with CED-6 CED-1 interaction with CED-2 CED-1 interaction with phospholipids on the surface of apoptotic cells CED-1 extracellular domain and transmembrane domain.

4 CED-1 intracellular domain is
Dispensable for recognition of apoptotic cells Important for cell corpse engulfment Shorter than its extracellular domain Potential target for phosphorylation All of the above


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